What is EN ISO 4772:2021?

EN ISO 4772:2021 is a technical standard that provides guidance for the determination of particle size distribution and particle count in nanomaterial dispersions using dynamic light scattering (DLS). This standard, developed by the International Organization for Standardization (ISO), aims to ensure accurate and reproducible measurements of particle size in various types of nanomaterials.

The importance of particle size characterization

Precise characterization of particle size in nanomaterial dispersions is crucial in both research and industrial applications. The behavior and properties of nanomaterials can vary significantly with their particle size, impacting their performance and safety. Therefore, understanding the particle size distribution is essential for quality control, process optimization, and regulatory compliance.

Principles of dynamic light scattering

Dynamic light scattering (DLS) is a widely used technique for determining the particle size distribution in nanomaterial dispersions. It works by analyzing the intensity fluctuations of scattered light caused by Brownian motion of nanoparticles. According to Stokes-Einstein equation, the diffusion coefficient of particles is inversely proportional to their size. By measuring the time-dependent fluctuations in scattered light intensity, DLS can calculate the particle size distribution in the sample.

Requirements and considerations in EN ISO 4772:2021

The EN ISO 4772:2021 standard outlines the specific requirements and considerations for performing accurate and reliable particle size measurements using DLS. It covers aspects such as instrument calibration, sample preparation, measurement conditions, data analysis methods, and reporting formats. Following this standard ensures consistency and comparability of results obtained from different laboratories or instruments.

Additionally, the standard highlights common sources of errors and provides guidelines to mitigate their impact on measurement accuracy. It emphasizes the importance of proper instrument validation and regular quality control checks to ensure reliable and traceable results. Furthermore, it addresses potential challenges associated with specific types of nanomaterials, such as agglomerates or aggregates, and suggests appropriate strategies for their characterization.

Overall, EN ISO 4772:2021 plays a crucial role in ensuring accurate and standardized particle size analysis of nanomaterial dispersions. Compliance with this technical standard enables researchers, manufacturers, and regulators to make informed decisions concerning the development, production, and safety assessment of nanotechnology-based products.